Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 37, Issue 2, Pages 168-174Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0133-3
Keywords
Schisandra sphenanthera; Triterpenoid; Cytotoxicity; Anti-HIV-1
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Funding
- Chinese Academy of Sciences [KSCX2-EW-Q-10]
- NSFC [81102483, 81001462, 30830115]
- Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]
- Key Scientific and Technological Program of China [2012ZX10001-006]
- project of recruited top talent of sciences and technology of Yunnan Province [2009C1120]
- Natural Science Foundation of Yunnan Province [2012FB178]
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Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 mu g ml(-1) and therapeutic index value of 117.12.
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