Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 50, Issue 3, Pages 531-540Publisher
WILEY
DOI: 10.1002/mrm.10568
Keywords
morphology; anisotropy; perfusion; MRI; capillaries
Funding
- Intramural NIH HHS [ZIA HL004606-13] Funding Source: Medline
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The intravoxel incoherent motion (IVIM) method was implemented in closed-chest dogs to obtain measurements on microcirculation in the left ventricular wall in vivo. Specifically, it enabled us to measure the mean microflow velocity (400 +/- 40 mum/s) and the vascular volume fraction (VVF) (11.1% +/- 2.2%), and observe the directional preference of capillary orientation. The apparent diffusion coefficients (ADCs) of water along and perpendicular to myofibers were also measured. With vasodilatation by adenosine infusion, a 25% increase in the VVF and a 7% increase in the mean microflow velocity were observed, while no change in the ADC was detected. A 28.5% decrease of the ADC was observed postmortem. Published 2003 Wiley-Liss, Inc.(dagger).
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