Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 37, Issue 3, Pages 371-378Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0179-2
Keywords
Baicalin; Rat; Intestinal bacteria; Kinetics; Metabolism
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Funding
- Korea Food & Drug Administration [09172KFDA996]
- National Research Foundation of Korea [2010-0026220]
- Yeungnam University [211-A-345-014]
- National Research Foundation of Korea [2010-0026220] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Baicalin (baicalein-7-glucuronide) is a flavonoid purified from Scutellaria baicalensis Georgi that has traditionally been used for treatment of hypertension, cardiovascular diseases, and viral hepatitis. In this study, the effects of intestinal microbiota on the pharmacokinetics of baicalin were investigated in normal and antibiotic-pretreated rats following p.o. administration of 100 mg/kg baicalin by using liquid chromatography/ion trap mass spectrometry. When rats were pretreated orally with cefadroxil, oxytetracycline and erythromycin for 3 days to control the number of intestinal bacteria, the pharmacokinetic parameters of oral baicalin were significantly affected by antibiotics: C-max, T-1/2(beta), K-el and AUC values were significantly changed compared to those in normal rats. These results indicate that intestinal microbiota might play a key role in the oral pharmacokinetics of baicalin.
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