Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 35, Issue 5, Pages 779-784Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-0503-2
Keywords
Sesquiterpenoid; Soft coral; Sinularia scabra
Categories
Funding
- Ministry of Education [97C031702]
- National Science Council of Taiwan [NSC 98-2113-M-110-002-MY3]
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Two new cadinane-type sesquiterpenoids, scabralins A (1) and B (2) were obtained from the soft coral Sinularia scabra. Metabolite 1 was shown to exhibit moderate to weak cytotoxicity against MCF-7, WiDr, Daoy, and HEp 2 cancer cell lines. Also, incubation with 10 A mu M compound 1 significantly inhibited the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
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