Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 122, Issue 5, Pages 768-770Publisher
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2003.04506.x
Keywords
hairy cell leukaemia; allopurinol; 2-chlorodeoxyadenosine (2-CdA); skin rash
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The purine nucleoside analogue 2-chlorodeoxy-adenosine (2-CdA) is currently considered by many as first-line therapy for hairy cell leukaemia. Cutaneous reactions have occasionally been reported with this drug, particularly if used with allopurinol. We report a high frequency of skin reactions in 15 consecutive patients with hairy cell leukaemia treated with 17 courses of 2-CdA. These reactions occurred only in those receiving allopurinol and, in two patients, were severe enough to warrant steroid therapy. The routine concomitant use of allopurinol is therefore not recommended in this setting.
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