Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 35, Issue 10, Pages 1757-1762Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-1007-9
Keywords
Aspergillus sulphureus; Decumbenones; Cytotoxic activity
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Funding
- Russian Foundation for Basic Research [RFBR N 11-04-00772-a, 12-03-31406]
- grant FEBRAS [12-III-B-05-073]
- Program of the Presidium RAS Molecular and Cell Biology
- President of the Russian Federation Program for Support of the Leading Scientific Schools [N 546.2012.4]
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A new decaline derivative, decumbenone C (1) along with four known compounds, decumbenones A (2) and B (3), diorcinol (4), and brevianamide F (5) were isolated from the marine fungus Aspergillus sulphureus KMM 4640. Decumbenone C shows potent cytotoxic activity against SK-MEL-5 human melanoma cells with IC50 values of 0.9 mu M.
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