Journal
BIOLOGY OF THE CELL
Volume 95, Issue 6, Pages 329-333Publisher
WILEY
DOI: 10.1016/S0248-4900(03)00081-9
Keywords
epilepsy; development; cell death; synapse; excitability
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Funding
- NIMH NIH HHS [MH054671] Funding Source: Medline
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Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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