Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 35, Issue 6, Pages 1009-1013Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-0608-7
Keywords
Hydrazones; N-(diaryl)acyl hydrazones; Antileishmanial; Antibacterial; Antifungal
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The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4'-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed.
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