Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 35, Issue 11, Pages 2007-2012Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-1118-3
Keywords
Atractylodes japonica; Atractylenolide I; 5-Lipoxygenase; Anti-allergy; Atopic dermatitis
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Funding
- research fund of Studies on the Identification of the Efficacy of Biologically Active Components from Oriental Herbal Medicines from Korean Food and Drug Administration
- post-BK21 project from the Ministry of Education, Korea
- Food & Drug Administration (KFDA), Republic of Korea [12172한약재989-1202] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Ministry of Food & Drug Safety (MFDS), Republic of Korea [12172한약재989] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과C6A2102] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although some anti-allergic activities of the rhizome of Atractylodes japonica have been previously reported, the active principle(s) for anti-allergic action is not fully elucidated and the effect of this plant material on atopic dermatitis (AD) is not known. In this study, the 70% ethanol extract of the rhizome of A. japonica was found to significantly inhibit 5-lipoxygenase (5-LOX)-catalyzed leukotrienes (LT) production from rat basophilic leukemia (RBL)-1 cells. From the extract of A. japonica, three major sesquiterpene derivatives including atractylenolide I, atractylenolide III and eudesma-4,7-dien-8-one were successfully isolated. Among these compounds, only atractylenolide I was shown to strongly inhibit 5-LOX from RBL-1 cells (IC50 = 18.6 mu M). To evaluate the effects of experimental AD, the ethanol extract of A. japonica (200 mg/day) was administered orally to hapten-treated NC/Nga mice which is an animal model of AD. It was firstly found that the extract significantly inhibited AD-like symptoms in mice, as judged by severity score and scratching behavior. Taken together, it is concluded that A. japonica possesses the inhibitory activity on 5-LOX and an animal model of AD, and atractylenolide I may contribute, at least in part, to these anti-allergic actions of A. japonica.
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