Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 34, Issue 3, Pages 377-382Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-0304-z
Keywords
Asteraceae; Traditional Chinese medicines; Antioxidant; DPPH
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Funding
- National Science Council, Taiwan, ROC [NSC 97-2313-B-150-002-MY3]
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Forty-one compounds including two new constituents, senecainin A (1) and 3-methoxyisonicotinic acid (2), were characterized from the methanol extracts of the whole plant of Senecio scandens. The structures of the new compounds were comprehensively established with the aid of 1D and 2D NMR spectroscopic and mass spectrometric analyses. The chemical structures of known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. In addition, the antioxidant activity of some of the isolates was examined in the DPPH free radical scavenging assay. Among the tested compounds, (-)-monoepoxylignanolide, (-)-pinoresinol and (-)-epi-pinoresinol displayed significant antioxidant bioactivity.
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