Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 34, Issue 10, Pages 1633-1637Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-1007-1
Keywords
beta-Resorcylic macrolide; Fusarium sp.; Antibacterial activity; Staphylococcus aureus; Antifungal activity; Cryptococcus neoformans
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Funding
- Thailand Research Fund [DBG5280020]
- Development and Promotion of Science and Technology Talents Project
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A new beta-resorcylic macrolide, 5'-hydroxyzearalenone (1), and six known beta-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.
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