Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 34, Issue 5, Pages 709-714Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-0502-8
Keywords
Curvularia sp.; Sea fan-derived fungus; Modiolide; Pyrone; Mycoepoxydiene; Antibacterial activity; Antifungal activity
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Funding
- Commission on Higher Education
- Thailand Research Fund [RTA5180007, PHD/0109/2550]
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Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7), mycoepoxydiene (8), and deacetylmycoepoxydiene (9). Their antimicrobial activity against Staphylococcus aureus ATCC 25923, methicillin-resistant S. aureus and Microsporum gypseum SH-MU-4 were examined.
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