Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 34, Issue 6, Pages 907-912Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-0607-0
Keywords
Halotolerant fungus; Wallemia sebi; Antibacterial activity; Cyclopentanopyridine alkaloid
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Funding
- National Basic Research Program of China [2010CB833800]
- Special Fund for Marine Scientific Research in the Public Interest of China [2010418022-3]
- National Natural Science Foundation of China [30670219]
- PCSIRT [IRT0944]
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A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher's method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 mu M. The absolute configurations of compounds 2-4 were determined for the first time.
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