Journal
FERTILITY AND STERILITY
Volume 80, Issue 3, Pages 571-576Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0015-0282(03)00795-7
Keywords
controlled ovarian stimulation; recombinant FSH; FSH receptor; Ser680Asn; pharmacogenetics; FRET; real-time PCR
Categories
Ask authors/readers for more resources
Objective: To evaluate the association between FSH efficacy and FSHR alleles. Design: Retrospective study. Setting: University-based fertility unit and a private center for biomedical research. Patient(s): One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were categorized as poor responders (less than or equal to3 ovarian follicles at the end of the cycle) or normal responders (>3 follicles). Intervention(s): Daily administration of exogenous FSH. Main Outcome Measure(s): Number of good or poor responders. Result(s): The allele frequency and genotype distribution of the Ser680Asn marker differed significantly between groups. Cycle cancellations were increased (21%) among women who were homozygous for Ser680 compared with Ser/Asn and Asn/Asn patients, and 36% of poor-responders were homozygous for Ser680. Conclusion(s): The results support a role for FSHR gene in COS outcome. However, the weight of this factor is probably low. The Ser680 allele may act in concert with other environmental and genetic factors that contribute to FSH efficacy. (C) 2003 by American Society for Reproductive Medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available