Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 33, Issue 10, Pages 1467-1473Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-1001-z
Keywords
Histone modification; Non-coding RNA; Stem cell; Neuron; Glia
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Funding
- Ministry of Education, Science and Technology [20100340, 2009-0089242]
- Seoul R BD program [20090656]
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How a cell fate is determined and how tremendously diverse cells are generated during development are interesting and intriguing questions to be solved before using the stem cells for therapeutic purpose. Recently, it has been suggested that epigenetic control by the histone modifying enzymes and non-coding RNAs play important roles in guiding stem cells to differentiate into neurons or glia. In this review, we discuss the recent outcomes and advances in understanding the histone modifying enzymes and non-coding RNAs during neural cell-type specification of stem cells.
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