Journal
NEUROBIOLOGY OF AGING
Volume 24, Issue 5, Pages 725-732Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0197-4580(02)00056-8
Keywords
estrogen; hippocampus; MRI; neuroprotection 1
Categories
Funding
- NIA NIH HHS [AG12975, R03 AG033751, AG10129] Funding Source: Medline
- NIDDK NIH HHS [R01 DK060753] Funding Source: Medline
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Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen. (C) 2002 Elsevier Science Inc. All rights reserved.
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