Journal
MOLECULAR GENETICS AND METABOLISM
Volume 80, Issue 1-2, Pages 11-26Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymgme.2003.08.009
Keywords
mitochondria; neurodegeneration; Alzheimer disease; Parkinson disease; Huntington disease; diabetes; cancer; succinate dehydrogenase
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Mitochondrial dysfunction secondary to mitochondrial and nuclear DNA mutations has been associated with energy deficiency in multiple organ systems and a variety of severe, often fatal, clinical syndromes. Although the production of energy is indeed the primary function of mitochondria, attention has also been directed toward their role producing reactive oxygen and nitrogen species and the subsequent widespread deleterious effects of these intermediates. The generation of toxic reactive intermediates has been implicated in a number of relatively common disorders, including neurodegenerative diseases, diabetes, and cancer. Understanding the role mitochondrial dysfunction plays in the pathogenesis of common disorders has provided unique insights into a number of diseases and offers hope for potential new therapies. (C) 2003 Elsevier Inc. All rights reserved.
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