Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 31, Issue 8, Pages 965-969Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-001-1252-z
Keywords
Atractylodes lancea; asteraceae; constituent; atractylenolide; dihydrobenzofuran; cytotoxicity
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Funding
- Commonweal Foundation of Jiangsu Province [M2004525]
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A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraccae), along with ten known Compounds, including atractylencilide II (2), phi-taraxasteryl acetate (3), taraxerol acetate (4). beta-sitosterol (5), stigmasterol (6), beta-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-beta-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and ail isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.
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