Journal
CLINICAL IMMUNOLOGY
Volume 108, Issue 3, Pages 263-273Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S1521-6616(03)00160-8
Keywords
complement; neutrophils; inflammation; rodent; mucosa; adhesion molecules
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Funding
- NIAID NIH HHS [AI49316] Funding Source: Medline
- NIGMS NIH HHS [R01-GM62134] Funding Source: Medline
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C5 is critical in the development of local mucosal damage and inflammation as well as in the development of remote organ injury after mesenteric ischemia/reperfusion (IR). To define the role of C5a in tissue injury, we treated wild-type mice with a cyclic hexapeptide C5a receptor antagonist (C5aRa) and administered recombinant C5a to C5 deficient (C5(-/-)) mice subjected to mesenteric IR. We demonstrate that at 2-h postreperfusion, C5a administered to C5(-/-) mice during IR induces limited intestinal mucosal injury but failed to cause remote lung injury despite the fact that it upregulated adhesion molecule expression. C5aRa treatment of C5+/+ mice undergoing IR limited local injury and prevented distant organ injury. We conclude that although C5a can trigger certain components of the IR induced injury, other mediators such as C5b-9 and local factors are needed for the complete expression of IR tissue damage. (C) 2003 Elsevier Inc. All rights reserved.
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