Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 31, Issue 6, Pages 698-704Publisher
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-001-1215-4
Keywords
dihydrocaffeoyl-polyamine conjugates; hydroxycinnamic acid amides; solid phase synthesis; antibacterial activity; MRSA; VRSA
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Bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl)polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells.
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