Journal
NATURE IMMUNOLOGY
Volume 4, Issue 9, Pages 907-912Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni962
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Funding
- NEI NIH HHS [F32 EY06985, P30 EYO06360, EY13459] Funding Source: Medline
- NIAID NIH HHS [AI R01524751] Funding Source: Medline
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Dendritic cells (DCs) are key regulators of immune responses that activate naive antigen-specific T lymphocytes. In draining lymph nodes, antigen-bearing DCs are reported to be rare and short-lived. How such small numbers of short-lived DCs can activate rare antigen-specific T cells is unclear. Here we show that after immunization of mouse skins by gene gun, the number of antigen-bearing DCs that migrate to draining lymph node is 100-fold higher than previously estimated and that they persist for approximately 2 weeks. The substantial frequency and longevity of DCs in situ ensures ample antigen presentation and stimulation for the rare antigen-specific T cells in draining lymph nodes.
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