Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 135, Issue 2, Pages 343-353Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2014.07.007
Keywords
Allergy; asthma; atopy; helminths; therapeutics; clinical trials; animal models; hygiene hypothesis
Categories
Funding
- National Institutes of Health
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Helminth infections are associated with decreased rates of autoimmunity and allergy, and several clinical studies have demonstrated that intentional infection with helminths can reduce symptoms of autoimmune diseases. In contrast, though numerous animal studies have demonstrated that helminth infections ameliorate allergic diseases, clinical trials in humans have not shown benefit. In this article, we review in detail the 2 human studies that have prospectively tested whether helminth infections protect against allergy. We next review the research designs and results obtained from animal studies, and compare these to the human trials. We then postulate possible reasons for the lack of efficacy observed in clinical trials to date and discuss potential future areas of research in this field.
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