Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 51, Issue 9, Pages 1245-1248Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/002215540305100916
Keywords
sperm protein 17; testis; spermatogenesis; immunohistochemistry
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Funding
- NCI NIH HHS [R01 CA 88434] Funding Source: Medline
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Sperm protein 17 (Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.
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