Journal
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
Volume 164, Issue 1, Pages 61-65Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archpediatrics.2009.241
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Funding
- Canadian Institutes of Health Research (CIHR) [HPR-85526, HHP-67262]
- Vancouver Coastal Health
- Health Canada
- National Institutes of Health (NIH) [R01 DA011591]
- Michael Smith Foundation for Health Research (MSFHR)
- National Institute on Drug Abuse
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA011591, DP1DA026182] Funding Source: NIH RePORTER
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Objective: To examine whether there were differential rates of hepatitis C virus (HCV) incidence in injecting drug-using youths who did and did not report involvement in survival sex work. Design: Data were derived from 2 prospective cohort studies of injecting drug users (May 1, 1996, to July 31, 2007). Analyses were restricted to HCV antibody negative youths who completed baseline and at least 1 follow-up assessment. Setting: Vancouver, British Columbia, Canada. Participants: Of 3074 injecting drug users, 364 (11.8%) were youths (aged 14-24 years) with a median age of 21.3 years and a duration of injecting drug use of 3 years. Main Exposure: Survival sex work involvement. Main Outcome Measure: The Kaplan-Meier method and Cox proportional hazards regression were used to compare HCV incidence among youths who did and did not report survival sex work. Results: Baseline HCV prevalence was 51%, with youths involved in survival sex work significantly more likely to be HCV antibody positive (60% vs 44%; P = .002). In baseline HCV antibody-negative youths, the cumulative HCV incidence at 36 months was significantly higher in those involved in survival sex work (68.4% vs 38.8%; P < .001). The HCV incidence density was 36.8 (95% confidence interval [CI], 24.2-53.5) per 100 person-years in youths reporting survival sex work involvement at baseline compared with 14.1 (9.4-20.3) per 100 person-years in youths not reporting survival sex work. In multivariate Cox proportional hazards analyses, survival sex work was the strongest predictor of elevated HCV incidence (adjusted relative hazard, 2.30; 95% CI, 1.27-4.15). Conclusion: This study calls attention to the critical need for evidence-based social and structural HCV prevention efforts that target youths engaged in survival sex work.
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