Journal
JOURNAL OF CELL SCIENCE
Volume 116, Issue 17, Pages 3453-3461Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00669
Keywords
unconventional myosin; Myo6; actin; receptor-mediated endocytosis; clathrin-coated pits; vesicle trafficking
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Actin is found at the cortex of the cell where endocytosis occurs, but does it play a role in this essential process? Recent studies on the unconventional myosin, myosin VI, an actin-based molecular motor, provide compelling evidence that this myosin and therefore actin is involved in two distinct steps of endocytosis in higher eukaryotes: the formation of clathrin-coated vesicles and the movement of nascent uncoated vesicles from the actin-rich cell periphery to the early endosome. Three distinct adapter proteins GIPC, Dab2 and SAP97 - that associate with the cargo-binding tail domain of myosin VI have been identified. These proteins may recruit myosin VI to its sites of action.
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