Journal
IUBMB LIFE
Volume 55, Issue 9, Pages 497-504Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15216540310001642072
Keywords
glucocorticoids (GC); glucocorticoid receptor (GR); nuclear factor kappa B (NF kappa B); activator protein-1 (AP-1); Toll-like receptors (TLRs)
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Glucocorticoids are among the most widely used agents for the treatment of inflammatory diseases. The primary mechanism of glucocorticoid action is via the glucocorticoid receptor (GR), which blocks the expression of proinflammatory cytokines and adhesion molecules. Repression of many pro-inflammatory genes occurs by inhibition of transcription factors including nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1). In this article, we discuss the physiological and molecular interaction that occurs between GR and proinflammatory cytokines signaling pathways.
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