4.4 Article

Nicotinamide ribosyl uptake mutants in Haemophilus influenzae

Journal

INFECTION AND IMMUNITY
Volume 71, Issue 9, Pages 5398-5401

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.9.5398-5401.2003

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The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.

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