Journal
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
Volume 55, Issue 2-3, Pages 167-172Publisher
URBAN & FISCHER VERLAG
DOI: 10.1078/0940-2993-00307
Keywords
cat; sarcoma; vaccine; local reaction; immunohistochemistry; enzyme histochemistry
Categories
Ask authors/readers for more resources
Histological examination of 38 nodular formations extirpated from the site of vaccine administration to cats disclosed 25 cases of sarcoma and 13 of granuloma. Average age of the cats bearing sarcoma was 8.75 years whereas granuloma occurred at average age of 1.9 year. This age-relationship of the lesions, as well as their similar morphologic features indicated a progression of chronic inflammatory changes to tumors. Similar tumors were diagnosed in one cat with posttraumatic ocular sarcoma and in the uterus of female-cat with long-standing pyometra. These two cats were 15 and 8 years old, respectively. Experimental study of local reaction 21 days after administration of commercial. lipid-adjuvanted vaccine revealed in young cats (age 9 months) a reaction to immunogen, whereas in old animals (age 10 to 15 years) there was a reaction to foreign material. The data suggest that chronic inflammation and age-related immunodeficiency are instrumental in pathogenesis of the vaccine-associated sarcoma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available