Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 24, Issue 9, Pages 441-443Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(03)00206-2
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- NIMH NIH HHS [R01 MH038752-19] Funding Source: Medline
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The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).
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