Journal
PHYTOTHERAPY RESEARCH
Volume 17, Issue 8, Pages 917-920Publisher
WILEY
DOI: 10.1002/ptr.1250
Keywords
radix Salviae miltiorrhiza (RSM); angiotensin converting enzyme (ACE); lithospermic acid B (LSB)
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The roots of Salviae miltiorrhiza (RSM) have been traditionally used for treatment of hypertensive disease in China, Korea, and Japan. Bioassay guided fractionation and purification as assayed by angiotensin converting enzyme (ACE) inhibitory assay resulted in the isolation of lithospermic acid B (LSB) as an active principle. The ACE plasma activities were significantly inhibited by the addition of LSB in a dose-dependent manner of which IC50 value was 86 mug/ml (120 muM). Moreover, angiotensin I-induced contraction was markedly attenuated by prior exposure of endothelium-intact aortic rings to LSB. These results suggest that RSM-induced antihypertensive effect may be, at least in part, due to ACE inhibitory effect of LSB. Copyright (C) 2003 John Wiley Sons, Ltd.
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