4.7 Article

Discordant resistance to kanamycin and amikacin in drug-resistant Mycobacterium tuberculosis

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 47, Issue 9, Pages 2971-2973

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.47.9.2971-2973.2003

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It is generally thought that there is full cross-resistance in Mycobacterium tuberculosis between the aminoglycoside drugs kanamycin and amikacin. However, kanamycin resistance and amikacin susceptibility were seen in 43 of 79 (54%) multidrug-resistant Estonian isolates, indicating that there might be a need to test the resistance of M. tuberculosis isolates to both drugs.

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