Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 26, Issue 9, Pages 719-722Publisher
PHARMACEUTICAL SOCIETY KOREA
DOI: 10.1007/BF02976680
Keywords
Pelvetia siliquosa; fucaceae; fucosterol; anti-oxidant enzymes; s-transaminases; CCl4-intoxication
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The anti-oxidant activities of fucosterol isolated from the marine algae Pelvetia siliquosa were investigated. Fucosterol exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCl4-intoxication in rats. Fucosterol inhibited the sGOT and sGPT activities by 25.57 and 63.16%, respectively. Fucosterol showed the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities by 33.89, 21.56 and 39.24%, respectively, in CCl4- intoxicated rats. These results suggest that fucosterol possess not only the anti-oxidant, but also the hepatoprotective activities in rats.
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