Journal
PHYTOCHEMISTRY
Volume 64, Issue 2, Pages 567-569Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(03)00208-5
Keywords
Tanacetum parthenium; flavonols; compositae; centaureidin; jaceidin; santin; mitotic blockers
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Bio-guided fractionation of an extract from Tanacetum parthenium showing activity as mitotic blocker allowed the isolation and identification of santin 3, jaceidin 2 and centaureidin 1. The latter two closely related flavonols, which, to the best of our knowledge. are isolated here together for the first time, form a mixture difficult to resolve and which is probably the reason for the confusion in the literature regarding their occurrence. Centaureidin 1 had an IC50 of 1 muM while jaceidin 2 and santin 3 were 200 times less active. (C) 2003 Elsevier Ltd. All rights reserved.
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