Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 23, Issue 9, Pages 1075-1084Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.WCB.0000084248.20114.B3
Keywords
tissue pO2; oxygen microelectrode; neural activity; functional brain imaging
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An understanding of the local changes in cerebral oxygen content accompanying functional brain activation is critical for making a valid signal interpretation of hemodynamic-based functional brain imaging. However, spatiotemporal relations between changes in tissue partial pressure of oxygen (Po-2) and induced neural activity remain incompletely understood. To characterize the local Po-2 response to the given neural activity, the authors simultaneously measured tissue Po-2 and neural activity in the identical region of guinea pig auditory cortex with an oxygen microelectrode (tip < 10 mum) and optical recording with voltaoe-sensitive dye (RH 795). In addition, a laser displacement gauge and a laser-Doppler flowmeter were used to monitor the spatial displacement and regional cerebral blood flow, respectively, in the Po-2 measurement region. In the activated region, tissue Po-2 initially decreased during the -3-seconds after the onset of acoustic stimuli, and then increased during the next similar to5 seconds. Such biphasic changes are consistently found in cortical layers I to IV. In addition, amplitude of the biphasic change was closely related to detected peak height of the optical signal changes. The results suggest that the initial decrease in tissue Po-2 is coupled to the induced neural activity and depends on response time of local increase in cerebral blood flow.
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