Journal
AUTOIMMUNITY REVIEWS
Volume 2, Issue 5, Pages 248-257Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1568-9972(03)00031-4
Keywords
hepatitis B surface antigen; immunogenetics; major histocompatibility complex; vaccine
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Funding
- NIAID NIH HHS [5R01 AI49730, 5R01 AI20720] Funding Source: Medline
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The major envelope protein of the hepatitis B virus (HBV), the HBsAg, constitutes the current preventative vaccine, which represents the first subunit viral vaccine developed. The genetics of the immune response to HBsAg has been extensively studied both in humans and mice. Murine studies begun over 20 years ago indicated that at least two MHC class II and one MHC class III genes regulate anti-HBs immune responses. Additional MHC-linked genes influence the immune responses to the higher molecular weight (pre-S) components of the HBV envelope. The murine studies predicted even more complex MHC gene regulation of human immune responses to the HBsAg and that complexity certainly has been demonstrated during the ensuing years. This brief review is an attempt to summarize our current understanding of the MHC genes that influence the immune response to the HBsAg and possible mechanisms of action. (C) 2003 Elsevier Science B.V All rights reserved.
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