Journal
GENES CHROMOSOMES & CANCER
Volume 38, Issue 1, Pages 13-21Publisher
WILEY-LISS
DOI: 10.1002/gcc.10248
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The homeobox gene PROXI is related to the Drosophila prospero gene, which is expressed in the developing central nervous system and lens-secreting cone cells. We found that the PROXI gene had missense and nonsense mutations in 4 of 29 hematologic cell lines analyzed. Decreased mRNA expression was also observed in half of these cell lines by RT-PCR. The restoration of PROXI gene expression after treatment with the demethylating agent 5-aza-2'-deoxycytidine, as well as bisulfite sequencing analysis, indicated that gene silencing is caused by DNA hypermethylation at intron I. Such hypermethylation was also seen in primary lymphomas (56.3%, 18/32) in a tumor-specific manner. These findings indicate that the profile of the PROXI gene corresponds to that of a candidate tumor-suppressor gene. (C) 2003 Wiley-Liss, Inc.
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