Journal
LEUKEMIA & LYMPHOMA
Volume 44, Issue 10, Pages 1819-1821Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1042819031000111071
Keywords
progressive multifocal leukoencephalopathy; Waldenstrom's macroglobulinaemia; JC virus; immunosuppressive treatment
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Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating neurological disorder caused by JC virus. Immunocompromised patients such as those with chronic lymphocytic leukemia, AIDS and following organ transplantation are at increased risk. We report a patient with PML complicating longstanding Waldenstrom's macroglobulinaemia. Although PML is a rare occurrence, the newer highly immunosuppressive treatment approaches for patients with lymphoproliferative disorders necessitate a high index of clinical suspicion. The diagnosis should be considered in patients with compatible clinical features who have received long-term immunosuppressive treatments recognized to impair cellular immunity.
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