Journal
TRENDS IN NEUROSCIENCES
Volume 26, Issue 9, Pages 461-463Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(03)00231-5
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- NIA NIH HHS [AG12954-11] Funding Source: Medline
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Modulation of the proteases; that process the amyloid precursor protein (APP) is a major therapeutic strategy for the treatment and prevention of Alzheimer's disease (AD). The discovery of a novel endogenous modulator of alpha-secretase-mediated, in preference to beta-secretase-mediated, cleavage of APP implicates sumoylation in the etiology of AD, and offers a new therapeutic target for intervention in APP processing.
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