4.4 Article

Synthesis and properties of a novel fluorescent nucleobase, naphthopyridopyrimidine

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 36, Pages 6871-6874

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)01740-4

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A new base-discriminating fluorescent nucleoside, NPP, that can sharply distinguish between A and G bases opposite NPP is described. The hybridization of an ODN probe containing NPP with a target DNA facilitates the judgment of the type of purine base located at a specific site on the target DNA. (C) 2003 Published by Elsevier Ltd.

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