Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 136, Issue 3, Pages 257-260Publisher
CONSULTANTS BUREAU
DOI: 10.1023/B:BEBM.0000008977.57795.69
Keywords
granulocyte; active oxygen forms; intracellular signaling; habitual abortion
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Generation of active oxygen forms by, blood granulocytes was studied in women with a history of habitual abortions (2-3 spontaneous abortions in the first trimester, undeveloped pregnancies). The level of spontaneous luminol-dependent chemiluminescence of nonfractionated peripheral blood was increased in this patient population (study group) in comparison with women with normal reproductive function (reference group). The two groups differed by the level of activation of respiratory burst induced by opsonized zymosan and by activity of isolated granulocytes in response to chemotactic peptide N-formyl-methionyl-leucyl-phenyl-alanine,(1-50 muM). Differences in the effects of inhibitor of tyrosine protein kinases and protein phosphatases and inhibitor of mitogen-activated proteinkinase p38 MAPK were detected. The results-attest to predisposition to oxidative stress and poor cytotoxic functions of granulocytes, in women with habitual abortions, which can be due to specific features of regulation of oxidase activity by tyrosine protein kinases and protein phosphatases and by p38 MAPK.
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