Journal
CELL CALCIUM
Volume 34, Issue 3, Pages 281-284Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0143-4160(03)00122-2
Keywords
fluorescence; intracellular; neuron; Zn2+; RhodZin-3
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Funding
- NIA NIH HHS [AG00919, AG00836] Funding Source: Medline
- NINDS NIH HHS [NS30884] Funding Source: Medline
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A novel cationic fluorescent zinc (Zn2+) indicator (RhodZin-3) with nanomolar affinity for Zn2+ has been synthesized. RhodZin-3 exhibits large pH-independent fluorescence increases in the orange region of the visible wavelength spectrum with increasing zinc concentrations, and no sensitivity to physiolovically relevant Ca2+ concentrations. Experiments in neuronal cell cultures show that RhodZin-3 effectively localizes into mitochondria and detects changes of intramitochondrial free Zn2+ ([Zn2+](m)). (C) 2003 Elsevier Science Ltd. All rights reserved.
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