Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 41, Issue 9, Pages 4471-4474Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.41.9.4471-4474.2003
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Funding
- NIAID NIH HHS [U19-AI45432, U19 AI045432] Funding Source: Medline
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The presence of mutations in specific regions of the katG, inhA, and ahpC genes was analyzed with 69 Mycobacterium tuberculosis isoniazid-resistant isolates from three Brazilian states. Point mutations in codon 315 of the katG gene were observed in 87.1, 60.9, and 60% of the isolates from Rio Grande do Sul, Rio de Janeiro, and Sao Paulo, respectively. Mutations in the inhA gene were identified only in one isolate from RJ State, and the ahpC promoter region revealed mutations in distinct positions in 12.9, 21.7, and 6.7% of the isolates from RS, RJ and SP, respectively.
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