Journal
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Volume 25, Issue 9, Pages 732-734Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00043426-200309000-00011
Keywords
acute undifferentiated leukemia; antifungal therapy; antimycotic therapy; children; disseminated aspergillosis; voriconazole
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Invasive fungal infection continues to pose a significant threat to immunocompromised patients. The authors describe a pediatric patient receiving chemotherapy for acute undifferentiated leukemia who developed presumptive Aspergillus species infection disseminated to lung, liver, spleen, and bone. The authors report the successful treatment of this infection with the addition of voriconazole, a triazole antimycotic, to treatment with amphotericin and surgical debridement, in the setting of ongoing intensive chemotherapy.
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