Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 4, Issue 9, Pages 738-743Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm1201
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Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.
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