Journal
LEUKEMIA & LYMPHOMA
Volume 44, Issue 10, Pages 1667-1674Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1042819031000097438
Keywords
multiple myeloma; T cell expansions; idiotype; immunotherapy
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Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an improved prognosis. This review aims to describe the various ways in which we have demonstrated the presence of such T cell clones, and to describe the phenotype of these cells. Finally, the specificities of these clinically important CD8+ T cell populations will be discussed in the context of immunotherapy.
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