Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 95, Issue 3, Pages 960-968Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00349.2003
Keywords
5 '-AMP-activated protein kinase; antioxidant capacity; mitochondrial enzymes; muscle fiber type composition; peroxisome proliferator-activated receptor-gamma coactivator-1 alpha; 5-aminoimidazole-4-carboxamide-1-beta-D; ribofuranoside; uncoupling protein 3
Categories
Ask authors/readers for more resources
This study was designed to determine the histological and metabolic effects of the administration of 5'-AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) for 14 successive days. AICAR treatment caused a significant decrease in the percentage of type IIB fibers and the concomitant increase in the percentage of type IIX fibers in extensor digitorum longus (EDL) muscle. The capillary density and the capillary-to-fiber ratio were not altered by AICAR. AICAR treatment increased the glycolytic and oxidative enzyme activities but not the antioxidant enzyme activities. The AICAR treatment increased the uncoupling protein 3 (UCP3) level in EDL and the peroxisome proliferator-activated receptor-gamma coactivator-1alpha protein level in the soleus and EDL muscles, whereas the myogenin level was not altered by AICAR. These results seem to imply that the chronic activation of AMPK alters such muscle histochemical and metabolic characteristics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available