Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 30, Pages 16152-16156Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b04773
Keywords
biosensor; pyrene; graphene quantum dots; fluorescence resonance energy transfer; microRNA
Funding
- Shanghai Municipal Science and Technology Commission [13DZ1940200, 15441905000]
- National Natural Science Foundation of China [11405013]
- Shanghai Yang Fan Plan [15YF1413300]
- Deanship of Scientific Research, College of Science Research Center, King Saud University
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A novel biosensor platform was developed for detection of microRNAs (miRNAs) based on graphene quantum dots (GQDs) and pyrene-functionalized molecular beacon probes (py-MBs), Pyrene was introduced to trigger specifically fluorescence resonance energy transfer (FRET) between GQDs and fluorescent dyes labeled on py-MBs, and the unique fluorescent intensity change produced a novel signal for detection of the target, The platform realized detection of miRNAs in a. wide range from 0.1 n.M to 200 nM with great discrimination abilities, as well as multidetection of different kinds of miRNAs, which paved a brand new way for miRNA. detection based on GQDs.
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