Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 142, Issue 1-2, Pages 10-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-5728(03)00260-1
Keywords
central nervous system; proinflammatory cytokines; macrophage activation; spinal cord injury; syringomyelia
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Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1beta (IL-1beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration. (C) 2003 Elsevier B.V. All rights reserved.
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