Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 9, Pages 1203-1206Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np030109v
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The structurally unique leupyrrins A(1) (1), A(2) (2), B-1 (3), B-2 (4), C (5), and D (6) were isolated as one of three groups of secondary metabolites from Sorangium cellulosum strains So ce705 and So ce690. An unusually substituted gamma-butyrolactone ring and pyrrole and oxazoline rings are embedded in a nonsymmetric macrodiolide core structure, giving rise to compounds 1-6 as members of a novel class of secondary metabolites. Leupyrrin A(1) (1) shows good biological activity against various fungi and eukaryotic cells.
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