Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 251, Issue 1-2, Pages 17-26Publisher
SPRINGER
DOI: 10.1023/A:1025401026441
Keywords
adenosine; myocardial infarction; cardiac remodeling
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Funding
- NHLBI NIH HHS [HL-03160] Funding Source: Medline
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The increasing incidence of congestive heart failure has stimulated efforts to develop pharmacologic strategies to prevent or reverse the associated process of adverse cardiac remodeling. The possibility of utilizing endogenously generated factors that are capable of inhibiting this process is beginning to be explored. Adenosine, has been described as a retaliatory autacoid with homeostatic activities in the regulation of myocardial blood flow, catecholamine release, and reduction of injury resulting from periods of ischemia. Adenosine exerts a variety of actions that are consistent with the concept that it can reduce or inhibit the process of cardiac remodeling. In this manuscript, the basics of adenosine metabolism, its cell surface receptors and beneficial actions on the cardiovascular system are reviewed. In addition new, in vitro and in vivo data will be presented supporting the concept that adenosine exerts actions that may ameliorate adverse cardiac remodeling.
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